Patients undergoing surgery for lumbar spinal stenosis experience unique courses of pain and disability: A group-based trajectory analysis

Jeffrey J Hebert, Edward Abraham, Niels Wedderkopp, Erin Bigney, Eden Richardson, Mariah Darling, Hamilton Hall, Charles G Fisher, Y Raja Rampersaud, Kenneth C Thomas, Bradley Jacobs, Michael Johnson, Jerome Paquet, Najmedden Attabib, Peter Jarzem, Eugene K Wai, Parham Rasoulinejad, Henry Ahn, Andrew Nataraj, Alexandra Stratton and Neil Manson

PLOS ONE, 2019, vol. 14, issue 11, 1-14

Abstract: Objective: Identify patient subgroups defined by trajectories of pain and disability following surgery for degenerative lumbar spinal stenosis, and investigate the construct validity of the subgroups by evaluating for meaningful differences in clinical outcomes. Methods: We recruited patients with degenerative lumbar spinal stenosis from 13 surgical spine centers who were deemed to be surgical candidates. Study outcomes (leg and back pain numeric rating scales, modified Oswestry disability index) were measured before surgery, and after 3, 12, and 24 months. Group-based trajectory models were developed to identify trajectory subgroups for leg pain, back pain, and pain-related disability. We examined for differences in the proportion of patients achieving minimum clinically important change in pain and disability (30%) and clinical success (50% reduction in disability or Oswestry score ≤22) 12 months from surgery. Results: Data from 548 patients (mean[SD] age = 66.7[9.1] years; 46% female) were included. The models estimated 3 unique trajectories for leg pain (excellent outcome = 14.4%, good outcome = 49.5%, poor outcome = 36.1%), back pain (excellent outcome = 13.1%, good outcome = 45.0%, poor outcome = 41.9%), and disability (excellent outcome = 30.8%, fair outcome = 40.1%, poor outcome = 29.1%). The construct validity of the trajectory subgroups was confirmed by between-trajectory group differences in the proportion of patients meeting thresholds for minimum clinically important change and clinical success after 12 postoperative months (p

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0224200

DOI: 10.1371/journal.pone.0224200

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