Quantitative assessment of interstitial lung disease in Sjögren’s syndrome

Pablo Guisado-Vasco, Mario Silva, Miguel Angel Duarte-Millán, Gianluca Sambataro, Chiara Bertolazzi, Mauro Pavone, Isabel Martín-Garrido, Oriol Martín-Segarra, José Manuel Luque-Pinilla, Daniele Santilli, Domenico Sambataro, Sebastiano E Torrisi, Ada Vancheri, Marwin Gutiérrez, Mayra Mejia, Stefano Palmucci, Flavio Mozzani, Jorge Rojas-Serrano, Carlo Vanchieri, Nicola Sverzellati and Alarico Ariani

PLOS ONE, 2019, vol. 14, issue 11, 1-13

Abstract: Background: Interstitial lung disease (ILD) is a frequent manifestation of Sjögren’s syndrome (SS), an autoimmune disease of salivary and lacrimal glands, and affects approximately 20% of patients. No clinical or serological features appear to be useful to predict its presence, severity or progression, and chest high-resolution computed tomography (CT) remains the gold standard for diagnosis. Semiquantitative CT (SQCT) based on visual assessment (Goh and Taouli scoring) can estimate ILD extent, although it is burdened by relevant intra- and interobserver variability. Quantitative chest CT (QCT) is a promising alternative modality to assess ILD severity. Aim: To determine whether QCT assessment can identify extensive or limited lung disease in patients with SS and ILD. Methods: This multi-center, cross-sectional and retrospective study enrolled patients with SS and a chest CT scan. SQCT assessment was carried out in a blinded and centralized manner to calculate both Goh and Taouli scores. An operator-independent analysis of all CT scans with the open-source software platform Horos was used to evaluate the QCT indices. Patients were classified according to the extent of ILD and differences in QCT index distribution were investigated with non-parametric tests. Results: From a total of 102 consecutive patients with SS, the prevalence of ILD was 35.3% (36/102). There was a statistically significant difference in QCT index distribution between the SS with ILD and SS without ILD groups (p 20% (by Goh score) had a QCT index statistically different from those with limited ILD extent (p

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0224772

DOI: 10.1371/journal.pone.0224772

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