A multicenter case control study of association of vitamin D with breast cancer among women in Karachi, Pakistan

Uzma Shamsi, Shaista Khan, Iqbal Azam, Aysha Habib Khan, Amir Maqbool, Mohammad Hanif, Tiffany Gill, Romaina Iqbal and David Callen

PLOS ONE, 2020, vol. 15, issue 1, 1-21

Abstract: Background: The prevalence of vitamin D inadequacy and breast cancer are both high among women living in Karachi, Pakistan. Methods: A matched case control study was conducted in two hospitals of Karachi, Pakistan to evaluate the association of vitamin D (serum 25-hydroxyvitamin D) concentrations, vitamin D supplementation and sun exposure with breast cancer among Pakistani women. A total of 411 newly diagnosed histologically confirmed primary breast cancer cases were enrolled and 784 controls, free of breast and any other cancers, were matched by age (year of birth ± 5 years), residence in the same geographic area and study site. Information was collected on sociodemographic history, history of vitamin D supplementation, past medical and obstetrical history, family history of breast cancer, sun exposure history, histopathology reports and anthropometric measurement and venous blood was collected to measure serum 25-hydroxyvitamin D (25(OH)D) concentration. Results: Compared to patients with sufficient serum vitamin D (>30 ng/ml), women with serum vitamin D deficiency (

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0225402

DOI: 10.1371/journal.pone.0225402

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