Four months vitamin D supplementation to vitamin D insufficient individuals does not improve muscular strength: A randomized controlled trial

Guri Grimnes, Julia Kubiak and Rolf Jorde

PLOS ONE, 2019, vol. 14, issue 12, 1-11

Abstract: Main objective: The inconsistent results on the effects of vitamin D on muscle strength reported by intervention trials may partly be explained by inclusion of vitamin D sufficient individuals. The main objective was to study whether vitamin D supplementation will improve muscle strength in men and women with low serum vitamin D status, as measured by 25-hydroxyvitamin D (25(OH)D) at baseline. Methods: 417 men and women aged 40–80 years were included and randomized to receive a loading dose of 100 000 IU (2500 ug) vitamin D3 followed by 20 000 IU (500 ug)/week, or placebo. Muscle strength was tested by dynamometers at baseline and after four months. Results: Serum 25(OH)D levels increased from 32.6±11.1 nmol/l to 88.8±19.4 nmol/l (p

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0225600

DOI: 10.1371/journal.pone.0225600

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