Cost-effectiveness of diagnostic algorithms including lateral-flow urine lipoarabinomannan for HIV-positive patients with symptoms of tuberculosis

Nadia Yakhelef, Martine Audibert, Gabriella Ferlazzo, Joseph Sitienei, Steve Wanjala, Francis Varaine, Maryline Bonnet and Helena Huerga

PLOS ONE, 2020, vol. 15, issue 1, 1-17

Abstract: Background: Tuberculosis (TB) is the leading cause of death among HIV-positive patients. We assessed the cost-effectiveness of including lateral-flow urine lipoarabinomannan (LF-LAM) in TB diagnostic algorithms for severely ill or immunosuppressed HIV-positive patients with symptoms of TB in Kenya. Methods: From a decision-analysis tree, ten diagnostic algorithms were elaborated and compared. All algorithms included clinical exam. The costs of each algorithm were calculated using a ‘micro-costing’ method. The efficacy was estimated through a prospective study that included severely ill or immunosuppressed (CD4

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0227138

DOI: 10.1371/journal.pone.0227138

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