Vitreous levels of Lipocalin-2 on patients with primary rhegmatogenous retinal detachment

Georgios Batsos, Eleni Christodoulou, Georgios Vartholomatos, Petros Galanis and Maria Stefaniotou

PLOS ONE, 2019, vol. 14, issue 12, 1-9

Abstract: Purpose: To measure vitreous levels of Lipocalin2 (LCN2) in patients with rhegmatogenous retinal detachment (RRD) and investigate potential association with presence of proliferative vitreoretinopathy (PVR). Materials and methods: Collection of undiluted vitreous samples from 24 patients suffering from RRD and 10 control patients undergoing vitrectomy for: vitreomacular traction (VMT) (n = 2), idiopathic epiretinal membrane (iERM) (n = 6) and full thickness macular hole (FTMH) (n = 2). Quantitative analysis of LCN2 has been made with flow cytometry. Lens status, duration of symptoms, quadrants of detachment, as well as level of PVR, were assessed. Statistical analysis included Mann-Whitney test, Kruskal-Wallis test, t-test, Spearman’s correlation coefficient and Fisher's exact test. Results: Median LCN2 was significantly higher in the RRD group as compared to control (p 2 quadrants, p

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0227266

DOI: 10.1371/journal.pone.0227266

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