Intake frequency of vegetables or seafoods negatively correlates with disease activity of rheumatoid arthritis

Isao Murakami, Kosaku Murakami, Motomu Hashimoto, Masao Tanaka, Hiromu Ito, Takao Fujii, Mie Torii, Kaori Ikeda, Akiko Kuwabara, Kiyoshi Tanaka, Akiko Yoshida, Shuji Akizuki, Ran Nakashima, Hajime Yoshifuji, Koichiro Ohmura, Takashi Usui, Satoshi Morita and Tsuneyo Mimori

PLOS ONE, 2020, vol. 15, issue 2, 1-11

Abstract: Objective: To clarify the relationship between dietary habit and disease activity of rheumatoid arthritis (RA). Methods: This study enrolled RA patients who met the ACR/EULAR 2010 classification criteria from Kyoto University Rheumatoid Arthritis Management Alliance (KURAMA) cohort in 2015. 22-item food frequency questionnaire (FFQ) was taken for the measurement of dietary habit in a single-institution cohort of RA (Kyoto University Rheumatoid Arthritis Management Alliance: KURAMA) in 2015. The disease activities of RA using the Disease Activity Score calculated based on the erythrocyte sedimentation rate (DAS28-ESR), Simplified Disease Activity Index (SDAI), Health Assessment Questionnaire (HAQ), and serum matrix metalloproteinase-3 (MMP-3) level, the use of disease-modifying anti-rheumatic drugs (DMARDs), disease duration, rheumatoid factor, anti-cyclic citrullinated antibody, and body mass index were also examined. All of them were combined and statistically analyzed. Results: 441 RA patients (81% women; mean age 65 years; mean disease duration 15 years) were enrolled from the KURAMA cohort. Average Disease Activity Score-28 using the erythrocyte sedimentation rate (DAS28-ESR) was 2.7. Univariate analysis showed that intake frequency of vegetables had a statistically significant negative correlation with disease activity markers, such as DAS28-ESR (ρ = −0.11, p

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0228852

DOI: 10.1371/journal.pone.0228852

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