A microbiome and metabolomic signature of phases of cutaneous healing identified by profiling sequential acute wounds of human skin: An exploratory study

Mohammed Ashrafi, Yun Xu, Howbeer Muhamadali, Iain White, Maxim Wilkinson, Katherine Hollywood, Mohamed Baguneid, Royston Goodacre and Ardeshir Bayat

PLOS ONE, 2020, vol. 15, issue 2, 1-26

Abstract: Profiling skin microbiome and metabolome has been utilised to gain further insight into wound healing processes. The aims of this multi-part temporal study in 11 volunteers were to analytically profile the dynamic wound tissue and headspace metabolome and sequence microbial communities in acute wound healing at days 0, 7, 14, 21 and 28, and to investigate their relationship to wound healing, using non-invasive quantitative devices. Metabolites were obtained using tissue extraction, sorbent and polydimethylsiloxane patches and analysed using GCMS. PCA of wound tissue metabolome clearly separated time points with 10 metabolites of 346 being involved in separation. Analysis of variance-simultaneous component analysis identified a statistical difference between the wound headspace metabolome, sites (P = 0.0024) and time points (P

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0229545

DOI: 10.1371/journal.pone.0229545

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