Fetuin-A in Metabolic syndrome: A systematic review and meta-analysis

Xiongfeng Pan, Shi Wu Wen, Prince L Bestman, Atipatsa C Kaminga, Kwabena Acheampong and Aizhong Liu

PLOS ONE, 2020, vol. 15, issue 3, 1-16

Abstract: Objective: Fetuin-A has been associated with the progression of metabolic syndrome, but previous studies found inconsistent results on the relationship between metabolic syndrome and the concentration of fetuin-A. The aim of this study was to perform a meta-analysis to summarize previous findings on this relationship. Method: This study was registered with the International Prospective Register of Systematic Reviews PROSPERO (CRD42019129566). Studies examining the relationship between metabolic syndrome and the concentration of circulating fetuin-A were identified using a systematic search in the electronic databases of Embase, PubMed, Web of Science, and Cochrane Library before March 2019. A random effects model was used to summarize the effect size of the association in terms of the standardized mean difference (SMD). Results: Fourteen eligible studies compared fetuin-A concentrations between 4,551 metabolic syndrome patients and 8,805 controls. The circulating fetuin-A concentration was significantly higher in the metabolic syndrome patients than in the controls (SMD = 0.65, 95% confidence interval (CI): 0.48 to 0.83, Z = 7.18, p

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0229776

DOI: 10.1371/journal.pone.0229776

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