Frailty transitions and associated clinical outcomes in patients with stable COPD: A longitudinal study

Roberto Bernabeu-Mora, Silvana Loana Oliveira-Sousa, Piedad Sánchez-Martínez Mª, Jose Antonio García-Vidal, Mariano Gacto-Sánchez and Francesc Medina-Mirapeix

PLOS ONE, 2020, vol. 15, issue 4, 1-13

Abstract: Background: Although frailty is a frequent occurrence in chronic obstructive pulmonary disease (COPD) patients, evidence on the frequency of frailty transition is scarce. Aims: The present study aimed to describe the frailty status transition rates over a 2-year period and their associated clinical outcomes in stable COPD patients, and to determine predictors of improvement in frailty status. Methods: We prospectively included 119 patients with stable COPD (mean age ± SD, 66.9 ± 7.9 years) over a follow-up period of 2 years. Frailty was assessed using the Fried criteria (unintentional weight loss, weakness, exhaustion, low activity level, and slow walking speed). Several demographic, clinical, and health-related variables were measured. We calculated the rates for each of the frailty transitions (no change, improvement, or worsening) between baseline and 2 years. Outcomes were compared using one-way analysis of variance and predictors of improvement were identified in multivariate logistic regression. Results: After 2 years of follow-up, 21 (17.6%) patients had an improved frailty status, 14 (11.7%) had worsened, and 84 (70.5%) had maintained the same frailty status. The worsening group (vs no change group) had greater dyspnea (p = 0.013) and disability (p = 0.036) and lower handgrip strength (p = 0.001). In contrast, the improved group (vs no change group) had greater handgrip (p

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0230116

DOI: 10.1371/journal.pone.0230116

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