Bone mineral density changes among people living with HIV who have started with TDF-containing regimen: A five-year prospective study

Win Min Han, Lalita Wattanachanya, Tanakorn Apornpong, Jureeporn Jantrapakde, Anchalee Avihingsanon, Stephen J Kerr, Nipat Teeratakulpisarn, Tanate Jadwattanakul, Tawatchai Chaiwatanarat, Patinut Buranasupkajorn, Reshmie Ramautarsing, Nittaya Phanuphak, Sarat Sunthornyothin, Kiat Ruxrungtham, Praphan Phanuphak and 003.1 Study Team Tnt

PLOS ONE, 2020, vol. 15, issue 3, 1-14

Abstract: There are limited data regarding long-term BMD changes over time among treatment-naïve people living with HIV (PLHIV) after initiating combined antiretroviral therapy (cART) in Asia. We aimed to study bone mineral density (BMD) changes among treatment-naïve PLHIV started treatment with tenofovir disoproxil fumarate (TDF)- or non-TDF-containing regimen and HIV-uninfected controls in an Asian setting. The study was a five-year prospective study. BMD at lumbar spine (LS) (L1 to L4), total hip (TH), and femoral neck (FN) were measured by dual energy X-ray absorptiometry (DEXA) scans at baseline, months 12, 24 and 60. Multivariate logistic regression models were used to explore factors associated with mean BMD ≥5% reduction after 5 years of cART. A total of 106 PLHIV (75 and 31 started TDF- and non-TDF-containing regimen, respectively) and 66 HIV-uninfected individuals were enrolled. The mean percent changes of BMD were significantly different longitudinally between TDF and non-TDF users (p

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0230368

DOI: 10.1371/journal.pone.0230368

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