Impact of systemic treatments on the course of HLA-B27-associated uveitis: A retrospective study of 101 patients

Nabil Bouzid, Yvan Jamilloux, Roland Chapurlat, Pierre Pradat, Audrey De Parisot, Laurent Kodjikian and Pascal Sève

PLOS ONE, 2020, vol. 15, issue 3, 1-12

Abstract: Purpose: To investigate the efficacy and tolerance of systemic treatments for the prevention of HLA-B27-associated acute uveitis (AU) recurrence. Methods: Retrospective review of patients with HLA-B27-associated uveitis followed in our tertiary center over a 15-year period. Systemic treatments were prescribed to patients with frequent (more than 2 flares per year) or severe uveitis, according to a step-up strategy Results: 101 patients (51.5% of men, 88.1% of white Europeans) with a median age of 37 years. AU was mostly recurrent (68.3%) and associated with spondyloarthritis (60.4%). After a median follow-up duration of 22 months (3–73), 37.6% of the patients have received systemic treatment. 88.5% of the patients have been treated with sulfasalazine (SSZ) for ophthalmologic purposes (23/26). Methotrexate (MTX) and anti-TNFα agents have been initiated for a rheumatologic indication in 81.8% (9/11) and 100% of the patients (13/13), respectively. The annual uveitis relapse rate significantly decreased on SSZ (0.37 recurrences/year versus baseline 2.46 recurrences/year; p

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0230560

DOI: 10.1371/journal.pone.0230560

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