Higher thresholds for the utilization of steatotic allografts in liver transplantation: Analysis from a U.S. national database

Justin A Steggerda, Matthew B Bloom, Mazen Noureddin, Todd V Brennan, Tsuyoshi Todo, Nicholas N Nissen, Andrew S Klein and Irene K Kim

PLOS ONE, 2020, vol. 15, issue 4, 1-17

Abstract: Background: Historically, liver allografts with >30% macrosteatosis (MaS) on donor biopsy have been associated with early allograft dysfunction and worse graft survival; however, successful outcomes have been reported in small cohorts. This study proposes an elevated MaS threshold for organ utilization without detriment to graft survival. Methods: The UNOS Standard Transplant Analysis and Research database was evaluated for transplants between 2006–2015. Graft survival up to 1-year was evaluated by Kaplan-Meier (KM) survival analyses, and by univariate and multivariable logistic regression analyses, including donor and recipient characteristics. Odds ratios (OR) with 95% confidence intervals (CI) for risk of graft loss are reported. Results: Thirty-day risk of graft loss was increased with MaS as low as 10–19% (OR [95% CI] 1.301 [1.055–1.605], p

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0230995

DOI: 10.1371/journal.pone.0230995

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