Optimization of time frame binning for FDOPA uptake quantification in glioma

Antoine Girard, Hervé Saint-Jalmes, Nibras Chaboub, Pierre-Jean Le Reste, Alice Metais, Anne Devillers, Florence Le Jeune and Xavier Palard-Novello

PLOS ONE, 2020, vol. 15, issue 4, 1-11

Abstract: Introduction: 3,4-dihydroxy-6-[18F]fluoro-L-phenylalanine (FDOPA) uptake quantification in glioma assessment can be distorted using a non-optimal time frame binning of time-activity curves (TAC). Under-sampling or over-sampling dynamic PET images induces significant variations on kinetic parameters quantification. We aimed to optimize temporal time frame binning for dynamic FDOPA PET imaging. Methods: Fourteen patients with 33 tumoral TAC with biopsy-proven gliomas were analysed. The mean SUVmax tumor-to-brain ratio (TBRmax) were compared at 20 min and 35 min post-injection (p.i). Five different time frame samplings within 20 min were compared: 11x10sec-6x15sec-5x20sec-3x300sec; 8x15sec– 2x30sec– 2x60sec– 3x300sec; 6x20sec– 8x60sec– 2x300sec; 10x30sec– 3x300sec and 4x45sec– 3x90sec– 5x150sec. The reversible single-tissue compartment model with blood volume parameter (VB) was selected using the Akaike information criterion. K1 values extracted from 1024 noisy simulated TAC using Monte Carlo method from the 5 different time samplings were compared to a target K1 value as the objective, which is the average of the K1 values extracted from the 33 lesions using an imaging-derived input function for each patient. Results: The mean TBRmax was significantly higher at 20 min p.i. than at 35 min p.i (respectively 1.4 +/- 0.8 and 1.2 +/- 0.6; p

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0232141

DOI: 10.1371/journal.pone.0232141

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