Age-related change in flicker thresholds with rod- and cone-enhanced stimuli

Amithavikram R Hathibelagal, Shrikant R Bharadwaj, Anil R Yadav, Ahalya Subramanian, James R E Sadler and John L Barbur

PLOS ONE, 2020, vol. 15, issue 7, 1-15

Abstract: Purpose: Rod and cone photoreceptor-specific tests can be time-consuming. A new non-invasive test is described. The test is based on the measurement of flicker modulation thresholds with rod- and cone-enhanced visual stimuli, which requires only minimum adaptation time. Here, we investigated how the rod-and cone-mediated flicker thresholds vary with age. Methods: Monocular thresholds with rod and cone–enhanced stimuli were measured in 140 healthy adults, (age range: 18–75 years), foveally (0°) and at four parafoveal locations, at an eccentricity of 5° in each of the four quadrants using five, adaptive, interleaved staircases. Temporal frequencies, stimulus sizes, background luminance and spectral composition, were adjusted appropriately to achieve approximately 1 log unit separation in sensitivity between the rod- and cone-enhanced stimuli. Spectrally calibrated, ‘neutral density’ filters were used to enable adequate control of display luminance for rod enhanced stimuli. Results: The magnitude of central and parafoveal rod thresholds was significantly higher than the central and parafoveal cone thresholds, respectively (p 45 years (Spearman correlation, ρ = 0.74, p

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0232784

DOI: 10.1371/journal.pone.0232784

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