Common gray and white matter abnormalities in schizophrenia and bipolar disorder

Dong-Kyun Lee, Hyeongrae Lee, Kyeongwoo Park, Euwon Joh, Chul-Eung Kim and Seunghyong Ryu

PLOS ONE, 2020, vol. 15, issue 5, 1-18

Abstract: This study aimed to investigate abnormalities in the gray matter and white matter (GM and WM, respectively) that are shared between schizophrenia (SZ) and bipolar disorder (BD). We used 3T-magnetic resonance imaging to examine patients with SZ, BD, or healthy control (HC) subjects (aged 20–50 years, N = 65 in each group). We generated modulated GM maps through voxel-based morphometry (VBM) for T1-weighted images and skeletonized fractional anisotropy, mean diffusion, and radial diffusivity maps through tract-based special statistics (TBSS) methods for diffusion tensor imaging (DTI) data. These data were analyzed using a generalized linear model with pairwise comparisons between groups with a family-wise error corrected P

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0232826

DOI: 10.1371/journal.pone.0232826

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