Indexation of left ventricular mass to predict adverse clinical outcomes in pre-dialysis patients with chronic kidney disease: KoreaN cohort study of the outcome in patients with chronic kidney disease

Sung Woo Lee, Hyang Ki Min, Dong-Wan Chae, Kook-Hwan Oh, Curie Ahn, Wookyung Chung, Joongyub Lee, Yong-Soo Kim, Su Ah Sung and Representing the KNOW-CKD Study Group

PLOS ONE, 2020, vol. 15, issue 5, 1-14

Abstract: Background: No study has compared the clinical impact of indexation of left ventricular mass (LVM) on adverse clinical outcomes in pre-dialysis patients with chronic kidney disease (CKD). Methods: We reviewed 2,101 patients from a large-scale multi-center prospective study that gathered anthropometric and echocardiographic measurements and clinical outcomes. The LVM was indexed as body surface area (LVMI-BSA) and height raised to the power of 2.7 (LVMI-H2.7). The main outcomes were composite renal and cardiovascular events and all-cause mortality. Left ventricular hypertrophy (LVH) was defined as the highest sex-specific quartile of LVMI-BSA or LVMI-H2.7. Results: During a mean period of 3.5 years, 692 patients developed composite outcomes (32.9%). The area under the curve at 5 year of LVM (60.6%) for composite outcome was smaller than that for LVMI-BSA (63.2%, P

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0233310

DOI: 10.1371/journal.pone.0233310

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