ATR-FTIR spectroscopy as adjunct method to the microscopic examination of hematoxylin and eosin-stained tissues in diagnosing lung cancer

Ruth Bangaoil, Abegail Santillan, Lara Mae Angeles, Lorenzo Abanilla, Antonio Lim, Ma Cristina Ramos, Allan Fellizar, Leonardo Guevarra and Pia Marie Albano

PLOS ONE, 2020, vol. 15, issue 5, 1-15

Abstract: Lung cancer remains the leading cause of cancer-related death worldwide. Since prognosis and treatment outcomes rely on fast and accurate diagnosis, there is a need for more cost-effective, sensitive, and specific method for lung cancer detection. Thus, this study aimed to determine the ability of ATR-FTIR in discriminating malignant from benign lung tissues and evaluate its concordance with H&E staining. Three (3) 5μm-thick sections were cut from formalin fixed paraffin embedded (FFPE) cell or tissue blocks from patients with lung lesions. The outer sections were H&E-stained and sent to two (2) pathologists to confirm the histopathologic diagnosis. The inner section was deparaffinized by standard xylene method and then subjected to ATR-FTIR analysis. Distinct spectral profiles that distinguished (p

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0233626

DOI: 10.1371/journal.pone.0233626

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