Prognostic value of LAT-1 status in solid cancer: A systematic review and meta-analysis

Jing-jing Lu, Ping Li, Yong Yang, Le Wang, Yan Zhang, Jia-yao Zhu, Xiao-ren Zhu and Min-bin Chen

PLOS ONE, 2020, vol. 15, issue 5, 1-16

Abstract: Background: The expression of the L-type amino acid transporter 1 (LAT1) plays a significant role in tumor progression. However, it remains unclear whether high LAT1 expression correlates with poor prognosis of solid tumor patients. Here, we conducted a meta-analysis to assess the potential of LAT1 in predicting the prognosis of tumor patients. Methods and findings: A total of 4,579 cases were analyzed from 35 qualified studies. In patients with solid tumors, elevated expression of LAT1 is associated with poor prognosis (overall survival [OS]: pooled hazard ratio (HR) = 1.848, 95% confidence interval (CI) = 1.620–2.108, P

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0233629

DOI: 10.1371/journal.pone.0233629

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