Influence of physical activity on serum vitamin D levels in people with multiple sclerosis

Angelika Bauer, Ivan Lechner, Michael Auer, Thomas Berger, Gabriel Bsteh, Franziska Di Pauli, Harald Hegen, Sebastian Wurth, Anne Zinganell and Florian Deisenhammer

PLOS ONE, 2020, vol. 15, issue 6, 1-9

Abstract: In most cases, multiple sclerosis (MS) patients reduce physical activity with disease progression and many patients are found to be vitamin D deficient. The aim of this study was to explore correlations between daily physical activity in everyday life and 25-hydroxyvitamin-D3 (25(OH)D3) serum levels in mildly disabled patients with an Expanded Disability Status Scale (EDSS) ≤ 4. We analyzed serum 25(OH)D3 levels and recorded daily physical activity (activity duration, number of steps, distance, energy expenditure) using an activity tracker for 14-days in 25 women and 15 men. Participants recorded their daily sunlight exposure time by diary during the study period. We found a positive correlation between physical activity and 25(OH)D3 levels in both, Pearson correlation (r = 0.221) and multivariate regression analysis (β = 0.236), which was stronger than correlation with sunlight exposure time (β = -0.081). EDSS and physical activity were weakly correlated (r = -0.228), but no correlation between EDSS and 25(OH)D3 levels was found (r = -0.077). There were no relevant differences in physical activity (p = 0.803) and 25(OH)D3 concentrations (p = 0.385) between the EDSS groups 0 – 1.5 and 2.0 – 4.0. In conclusion, physical activity has an effect on vitamin D levels independent of sunlight exposure time in people with MS (pwMS) with low-grade disability.

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0234333

DOI: 10.1371/journal.pone.0234333

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