Outcomes of decitabine treatment for newly diagnosed acute myeloid leukemia in older adults​

Kwai Han Yoo, Jinhyun Cho, Boram Han, Se Hyung Kim, Dong-Yeop Shin, Junshik Hong, Hawk Kim, Hyo Jung Kim, Dae young Zang, Sung-Soo Yoon, Jong-Youl Jin, Jae Hoon Lee, Dae-Sik Hong and Seong Kyu Park

PLOS ONE, 2020, vol. 15, issue 8, 1-12

Abstract: Purpose: We evaluated the outcomes of decitabine as first-line treatment in older patients with acute myeloid leukemia (AML) and investigated the predictors, including a baseline mini nutritional assessment short form (MNA-SF) score, of response and survival. Patients and methods: Between 2010 and 2018, 96 AML patients aged 65 and above who received decitabine treatment at 6 centers in Korea were retrospectively evaluated. Response rates, hematologic improvements (HI), progression-free survival (PFS), and overall survival (OS) were analyzed. Results: The median age at diagnosis was 73.9 years, and the median number of decitabine treatments administered to the patients was 4 (range, 1−29). Of 85 patients, 15 patients (17.6%) achieved complete remission (CR) or CR with incomplete blood count recovery. Twelve patients (14.1%) showed partial remission (PR), and 18 (21.2%) demonstrated HI without an objective response. The median PFS and OS were 7.0 (95% confidence interval [CI], 4.9−9.0) and 10.6 (95% CI, 7.7−13.5%) months, respectively. In multivariate analyses, MNA-SF score ≥ 8 and the absence of peripheral blood (PB) blasts were significant predictors for improved PFS and OS. Conclusions: For older patients with newly diagnosed AML, a high MNA-SF score and the absence of PB blasts were independently associated with improved survival.

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0235503

DOI: 10.1371/journal.pone.0235503

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