The extravasation of contrast as a predictor of cerebral hemorrhagic contusion expansion, poor neurological outcome and mortality after traumatic brain injury: A systematic review and meta-analysis

Isabella Vargas Baldon, Andre Candeas Amorim, Larissa Marques Santana, Davi J Solla, Angelos Kolias, Peter Hutchinson, Wellingson S Paiva and Marcos Rosa-Júnior

PLOS ONE, 2020, vol. 15, issue 7, 1-12

Abstract: Background: The active extravasation of contrast on CT angiography (CTA) in primary intracerebral hemorrhages (ICH) is recognized as a predictive factor for ICH expansion, unfavorable outcomes and mortality. However, few studies have been conducted on the setting of traumatic brain injury (TBI). Purpose: To perform a literature systematic review and meta-analysis of the association of contrast extravasation on cerebral hemorrhagic contusion expansion, neurological outcomes and mortality. Data sources: The PubMed, Cochrane Library, Medline, Scielo, VHL and IBECS databases up to September 21, 2019, were searched for eligible studies. Study selection: A total of 505 individual titles and abstracts were identified and screened. A total of 36 were selected for full text analysis, out of which 4 fulfilled all inclusion and exclusion criteria. Data analysis: All 4 studies yielded point estimates suggestive of higher risk for hematoma expansion with contrast extravasation and the summary RR was 5.75 (95%CI 2.74–10.47, p

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0235561

DOI: 10.1371/journal.pone.0235561

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