Distinct association between cerebral arterial pulsatility and subtypes of cerebral small vessel disease

Ki-Woong Nam, Hyung-Min Kwon and Yong-Seok Lee

PLOS ONE, 2020, vol. 15, issue 7, 1-11

Abstract: Background: Increased arterial resistance is a potential pathological mechanism of cerebral small vessel disease (cSVD). Aim: In this study, we aimed to investigate the association between pulsatility index (PI) representing cerebral arterial resistance and subtypes of cSVD in patients with lacunar stroke. Methods: We included consecutive lacunar stroke patients between 2010 and 2013. White matter hyperintensity (WMH) volume was rated using semi-automated quantitative methods. Additionally, the presence of old lacunar infarct (OLI), cerebral microbleed (CMB), or enlarged perivascular space (EPVS) was also evaluated. The relationship between PI, measured in each middle cerebral artery, and the subtype/burden of cSVD was analyzed in the relevant hemisphere. Results: A total of 206 lacunar patients were included and 412 hemispheres were analyzed (mean age: 64 years, male: 68.4%). In multivariable analysis, PI was positively associated with the WMH volume [beta = 1.372, 95% confidence interval (CI) = 0.624 to 2.120, P

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0236049

DOI: 10.1371/journal.pone.0236049

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