Prediction model and risk scores of ICU admission and mortality in COVID-19

Zirun Zhao, Anne Chen, Wei Hou, James M Graham, Haifang Li, Paul S Richman, Henry C Thode, Adam J Singer and Tim Q Duong

PLOS ONE, 2020, vol. 15, issue 7, 1-14

Abstract: This study aimed to develop risk scores based on clinical characteristics at presentation to predict intensive care unit (ICU) admission and mortality in COVID-19 patients. 641 hospitalized patients with laboratory-confirmed COVID-19 were selected from 4997 persons under investigation. We performed a retrospective review of medical records of demographics, comorbidities and laboratory tests at the initial presentation. Primary outcomes were ICU admission and death. Logistic regression was used to identify independent clinical variables predicting the two outcomes. The model was validated by splitting the data into 70% for training and 30% for testing. Performance accuracy was evaluated using area under the curve (AUC) of the receiver operating characteristic analysis (ROC). Five significant variables predicting ICU admission were lactate dehydrogenase, procalcitonin, pulse oxygen saturation, smoking history, and lymphocyte count. Seven significant variables predicting mortality were heart failure, procalcitonin, lactate dehydrogenase, chronic obstructive pulmonary disease, pulse oxygen saturation, heart rate, and age. The mortality group uniquely contained cardiopulmonary variables. The risk score model yielded good accuracy with an AUC of 0.74 ([95% CI, 0.63–0.85], p = 0.001) for predicting ICU admission and 0.83 ([95% CI, 0.73–0.92], p

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0236618

DOI: 10.1371/journal.pone.0236618

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