Safety, tolerability, and clinical outcomes of hydroxychloroquine for hospitalized patients with coronavirus 2019 disease

Michael J Satlin, Parag Goyal, Reed Magleby, Grace A Maldarelli, Khanh Pham, Maiko Kondo, Edward J Schenck, Hanna Rennert, Lars F Westblade, Justin J Choi, Monika M Safford and Roy M Gulick

PLOS ONE, 2020, vol. 15, issue 7, 1-14

Abstract: Background: Severe acute respiratory coronavirus 2 (SARS-CoV-2) has caused a devastating worldwide pandemic. Hydroxychloroquine (HCQ) has in vitro activity against SARS-CoV-2, but clinical data supporting HCQ for coronavirus disease 2019 (COVID-19) are limited. Methods: This was a retrospective cohort study of hospitalized patients with COVID-19 who received ≥1 dose of HCQ at two New York City hospitals. We measured incident Grade 3 or 4 blood count and liver test abnormalities, ventricular arrhythmias, and vomiting and diarrhea within 10 days after HCQ initiation, and the proportion of patients who completed HCQ therapy. We also describe changes in Sequential Organ Failure Assessment hypoxia scores between baseline and day 10 after HCQ initiation and in-hospital mortality. Results: None of the 153 hospitalized patients with COVID-19 who received HCQ developed a sustained ventricular tachyarrhythmia. Incident blood count and liver test abnormalities occurred in

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0236778

DOI: 10.1371/journal.pone.0236778

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