Developing target product profiles for Neisseria gonorrhoeae diagnostics in the context of antimicrobial resistance: An expert consensus

Cecilia Ferreyra, Jennifer Osborn, Francis Moussy, Emilie Alirol, Monica Lahra, David Whiley, William Shafer, Magnus Unemo, Jeffrey Klausner, Cassandra Kelly Cirino and Teodora Wi

PLOS ONE, 2020, vol. 15, issue 9, 1-15

Abstract: Background: There is a need for a rapid diagnostic point of care test to detect Neisseria gonorrhoeae (NG) infection to prevent incorrect, lack or excess of treatment resulting from current syndromic management in low-resource settings. An assay to identify NG antimicrobial resistance (AMR) is also highly desirable to facilitate antibiotic stewardship. Here we describe the development of two target product profiles (TPPs): one for a test for etiological diagnosis of NG and Chlamydia trachomatis (CT) (TPP1) and one for the detection of NG AMR/susceptibility (TPP2). Methods: Draft TPPs were initially developed based on a landscape analysis of existing diagnostics and expert input. TPPs were refined via an online Delphi survey with two rounds of input from 68 respondents. TPP characteristics on which

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0237424

DOI: 10.1371/journal.pone.0237424

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