Morphologic analysis of macular neovascularizations by OCT angiography—Technical limitations in the comparison of 3×3mm and 6×6mm images

Henrik Faatz, Kai Rothaus, Marie-Louise Gunnemann, Marius Book, Pia Wilming, Matthias Gutfleisch, Georg Spital, Albrecht Lommatzsch and Daniel Pauleikhoff

PLOS ONE, 2020, vol. 15, issue 8, 1-11

Abstract: Background: The aim of this study was to ascertain whether there are relevant differences between the vascular morphology of macular neovascularizations (MNV) in 3×3mm and 6×6mm images, produced by optical coherence tomography angiography (OCTA). Methods: MNV of 49 patients were automated quantitative analysed, measuring area, flow, the fractal dimension, average vessel length, vascular density, and average vessel caliber. These parameters were compared between the 3×3mm and the 6×6mm images. Results: A strong linear association was found between the 3×3mm and the 6×6mm images. While area, flow, and FD of the MNV were very similar, the 3×3mm images showed significantly lower average total vessel length, greater vascular density, and lower average vessel caliber. Conclusion: In quantitative analysis of the morphologic parameters of MNV in 3×3mm and 6×6mm images, the structures are not directly equivalent in the two sizes of scan. The images must be evaluated on an individual basis.

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0237785

DOI: 10.1371/journal.pone.0237785

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