Prognostic effect of pretreatment albumin-to-alkaline phosphatase ratio in human cancers: A meta-analysis

Xiaoli Guo, Qijiu Zou, Jiaxin Yan, Xingxing Zhen and Hongmei Gu

PLOS ONE, 2020, vol. 15, issue 8, 1-14

Abstract: Purpose: It has been demonstrated that, for various types of cancer, the pretreatment albumin/alkaline phosphatase ratio (AAPR) was a prognostic factor. Therefore, in order to determine AAPR’s prognostic effect on cancer, the meta-analysis was hereby performed. Patients and methods: The relevant studies conducted before November 10, 2019, were comprehensively searched in Web of Science, PubMed, and Embase. HRs(hazard ratios) with related 95%CIs(confidence intervals) were adopted to estimate AAPR’s prognostic impact on overall survival (OS) & disease-free survival (DFS). Results: Our meta-analysis involved thirteen cohort studies, which included 5,204 cases of 8 types. The results of this meta-analysis indicated that higher AAPR was corrected with better OS (pooled HR = 0.52; 95%CI = 0.47–0.58; P

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0237793

DOI: 10.1371/journal.pone.0237793

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