Cognition and motor function: The gait and cognition pooled index

Jacqueline K Kueper, Daniel J Lizotte, Manuel Montero-Odasso, Mark Speechley and for the Alzheimer’s Disease Neuroimaging Initiative

PLOS ONE, 2020, vol. 15, issue 9, 1-16

Abstract: Background: There is a need for outcome measures with improved responsiveness to changes in pre-dementia populations. Both cognitive and motor function play important roles in neurodegeneration; motor function decline is detectable at early stages of cognitive decline. This proof of principle study used a Pooled Index approach to evaluate improved responsiveness of the predominant outcome measure (ADAS-Cog: Alzheimer’s Disease Assessment Scale-Cognitive Subscale) when assessment of motor function is added. Methods: Candidate Pooled Index variables were selected based on theoretical importance and pairwise correlation coefficients. Kruskal-Wallis and Mann-Whitney U tests assessed baseline discrimination. Standardized response means assessed responsiveness to longitudinal change. Results: Final selected variables for the Pooled Index include gait velocity, dual-task cost of gait velocity, and an ADAS-Cog-Proxy (statistical approximation of the ADAS-Cog using similar cognitive tests). The Pooled Index and ADAS-Cog-Proxy scores had similar ability to discriminate between pre-dementia syndromes. The Pooled Index demonstrated trends of similar or greater responsiveness to longitudinal decline than ADAS-Cog-Proxy scores. Conclusion: Adding motor function assessments to the ADAS-Cog may improve responsiveness in pre-dementia populations.

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0238690

DOI: 10.1371/journal.pone.0238690

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