Risk factors for lower extremity amputation in patients with diabetic foot ulcers: A meta-analysis

Chunmei Lin, Jinhao Liu and Hu Sun

PLOS ONE, 2020, vol. 15, issue 9, 1-15

Abstract: Purpose: A considerable number of diabetic foot ulcer (DFU) patients require amputation every year, which worsens their quality of life, aggravates the social burden, and shortens their life expectancy. Considering these negative effects, it is important to explore the relative risk factors affecting amputation in DFU patients. Methods: The PubMed, SCIE and Embase databases were comprehensively searched for prospective or retrospective studies published before October 31, 2019. All English language studies involving DFU patients were included, and RevMan 5.3 software was used to analyse the data. Results: This meta-analysis includes 21 studies involving 6505 participants, including 2006 patients who required a lower limb amputation. The following variables were associated with an increased risk of amputation: male sex (odds ratios (OR) = 1.30, 95% confidence interval (CI) = 1.16~1.46, P

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0239236

DOI: 10.1371/journal.pone.0239236

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