MiR103a-3p and miR107 are related to adaptive coping in a cluster of fibromyalgia patients

Alexandra Braun, Dimitar Evdokimov, Johanna Frank, Claudia Sommer and Nurcan Üçeyler

PLOS ONE, 2020, vol. 15, issue 9, 1-12

Abstract: Background: MicroRNA (miRNA) mainly inhibit post-transcriptional gene expression of specific targets and may modulate disease severity. Objective: We aimed to identify miRNA signatures distinguishing patient clusters with fibromyalgia syndrome (FMS). Subjects and methods: We previously determined four FMS patient clusters labelled “maladaptive”, “adaptive”, “vulnerable”, and “resilient”. Here, we cluster-wise assessed relative gene expression of miR103a-3p, miR107, miR130a-3p, and miR125a-5p in white blood cell (WBC) RNA of 31 FMS patients and 16 healthy controls. Sum scores of pain-, stress-, and resilience-related questionnaires were correlated with miRNA relative gene expression. A cluster-specific speculative model of a miRNA-mediated regulatory cycle was proposed, and its potential targets verified by the online tool “target scan human”. Results: One-way ANOVA revealed lower gene expression of miR103a-3p, miR107, and miR130a-3p in FMS patients compared to controls (p

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0239286

DOI: 10.1371/journal.pone.0239286

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