Effectiveness of four antiretroviral regimens for treating people living with HIV

Aracele Tenório de Almeida e Cavalcanti, Ricardo Arraes de Alencar Ximenes, Ulysses Ramos Montarroyos, Polyana Monteiro d’Albuquerque, Rosário Antunes Fonseca and Demócrito de Barros Miranda-Filho

PLOS ONE, 2020, vol. 15, issue 9, 1-17

Abstract: The aim of this study was to compare 4 different ARV regimens in a clinical cohort in Brazil, with regard to the virologic and immunologic responses, clinical failure and reasons for changing. To compare the virologic response and clinical failure between groups we used the Cox and Kaplan Meier proportional hazard models. To analyze the immunologic outcome, we used multilevel GLLAMM and mixed effect linear regression models. To compare regimen change outcomes we used the Pearson's chi-square test. We included 840 participants distributed across the groups according to the initial ART regimen. The mean follow-up period was 27.8 months. Almost half the sample initiated ART with AIDS-related signs/symptoms. Virologic response was effective in 79.6% of participants within 12 months. The tenofovir/lamivudine/efavirenz group presented a higher proportion of virologic response (VL

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0239527

DOI: 10.1371/journal.pone.0239527

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