Characteristics of the inner retinal layer in the fellow eyes of patients with unilateral exudative age-related macular degeneration

Seong Eun Lee, Hyung Bin Lim, Yong Il Shin, Cheon Kuk Ryu, Woo Hyuk Lee and Jung-Yeul Kim

PLOS ONE, 2020, vol. 15, issue 9, 1-13

Abstract: Objective: To investigate the thicknesses of the ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL) of the fellow eyes of patients with unilateral exudative age-related macular degeneration (AMD). Methods: A total of 107 patients with unilateral exudative AMD [34 of typical choroidal neovascularization (tCNV), Group A; 73 of polypoidal choroidal vasculopathy (PCV), Group B] and 73 normal control eyes (Group C) were included. Drusen and subretinal drusenoid deposits were assessed in all participants using fundus photography, autofluorescence, and optical coherence tomography (OCT). The GC-IPL and RNFL thicknesses were measured using Cirrus HD-OCT and compared among groups. Linear regression analyses were used to evaluate the factors associated with GC-IPL thicknesses. Results: The average GC-IPL thicknesses of Groups A, B, and C were 77.09 ± 3.87, 80.10 ± 6.61, and 80.88 ± 6.50 μm, respectively (p = 0.022). Sectoral GC-IPLs and central macular thicknesses (CMTs) were significantly different among groups (all, p 0.05). Multivariate linear regression analyses revealed that age (p

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0239555

DOI: 10.1371/journal.pone.0239555

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