J-shaped relationship between cardiovascular risk and efficacy of intensive blood pressure reduction: A post-hoc analysis of the SPRINT trial

Armin Attar, Fatemeh Nouri, Roham Borazjani and Mehrab Sayadi

PLOS ONE, 2020, vol. 15, issue 10, 1-12

Abstract: Background: In the 2017 ACC/AHA hypertension guidelines, a 10-year risk of more than 10% is considered for initiation of intensive blood pressure reduction. The current study aimed to determine which cut off limit of cardiovascular risk for starting intensive blood pressure reduction is beneficial. Design: A Secondary Analysis of Systolic Blood Pressure Intervention Trial (SPRINT). Methods: Data from the SPRINT Trial was obtained from the NHLBI Data Repository Center. In the SPRINT, non-diabetic participants with SBP of ≥ 130 mmHg were randomly assigned to intensive and standard treatment arms with SBP targets of

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0240102

DOI: 10.1371/journal.pone.0240102

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