The association between osteopontin and tuberculosis: A systematic review and meta-analysis

Dongguang Wang, Xiang Tong, Lian Wang, Shijie Zhang, Jizhen Huang, Li Zhang and Hong Fan

PLOS ONE, 2020, vol. 15, issue 12, 1-14

Abstract: Objective: We examined the data reported in the studies for comparison of osteopontin (OPN) levels in tuberculosis and healthy participants, and to discuss whether OPN could be extended to disease diagnosis, severity assessment and therapeutic effect monitering. Methods: A systematic literature search was conducted in PubMed, EMBASE, Scopus, the Cochrane Library, Web of Science, the China National Knowledge Infrastructure (CNKI) and WanFang databases. The pooled risk estimates were shown in standardized mean difference (SMD) with 95% confidence interval (CI) for OPN levels. The random effect model was used according to the test of heterogeneity among studies. Subgroup analyses and meta-regression models were performed to identify the possible sources of heterogeneity. Results: 17 retrospective studies with 933 tuberculosis participants and 786 healthy controls were finally included in this article. In the primary meta-analysis, higher serum/plasma OPN levels were found in tuberculosis patients (SMD = 2.58, 95%CI = 2.09~3.08, P

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0242702

DOI: 10.1371/journal.pone.0242702

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