Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study

Margherita Torti, Chiara Fossati, Miriam Casali, Maria Francesca De Pandis, Paola Grassini, Fabiana Giada Radicati, Paola Stirpe, Laura Vacca, Ivo Iavicoli, Veruscka Leso, Marcello Ceppi, Marco Bruzzone, Stefano Bonassi and Fabrizio Stocchi

PLOS ONE, 2020, vol. 15, issue 12, 1-15

Abstract: Background: The aetiology of Parkinson’s disease (PD) is still very controversial, with a peculiar lack of established risk factors or protective behavior. Methods: We carried out a case–control study of 634 idiopathic PD patients admitted from 2011 to 2015 to two hospitals located in central Italy and 532 controls matched by hospital, gender and age (± 5 years). The study questionnaire included questions on host factors, family history, residence, occupation and lifestyle. Odds ratios (ORs) for PD and 95% confidence intervals (CIs) were estimated with logistic regression, adjusting for actual and potential confounders. Results: A lower OR was observed in females (0.74; 95%CI:0.58–0.96), while older age classes showed a constantly increased risk for PD (p

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0243612

DOI: 10.1371/journal.pone.0243612

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