Systematic review and meta-analysis of late auditory evoked potentials as a candidate biomarker in the assessment of tinnitus

Emilie Cardon, Iris Joossen, Hanne Vermeersch, Laure Jacquemin, Griet Mertens, Olivier M Vanderveken, Vedat Topsakal, Paul Van de Heyning, Vincent Van Rompaey and Annick Gilles

PLOS ONE, 2020, vol. 15, issue 12, 1-20

Abstract: Subjective tinnitus, the perception of sound in the absence of any sound source, is routinely assessed using questionnaires. The subjective nature of these tools hampers objective evaluation of tinnitus presence, severity and treatment effects. Late auditory evoked potentials (LAEPs) might be considered as a potential biomarker for assessing tinnitus complaints. Using a multivariate meta-analytic model including data from twenty-one studies, we determined the LAEP components differing systematically between tinnitus patients and controls. Results from this model indicate that amplitude of the P300 component is lower in tinnitus patients (standardized mean difference (SMD) = -0.83, p

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0243785

DOI: 10.1371/journal.pone.0243785

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