Ischemic stroke in PAR1 KO mice: Decreased brain plasmin and thrombin activity along with decreased infarct volume

Efrat Shavit-Stein, Ekaterina Mindel, Shany Guly Gofrit, Joab Chapman and Nicola Maggio

PLOS ONE, 2021, vol. 16, issue 3, 1-12

Abstract: Background: Ischemic stroke is a common and debilitating disease with limited treatment options. Protease activated receptor 1 (PAR1) is a fundamental cell signaling mediator in the central nervous system (CNS). It can be activated by many proteases including thrombin and plasmin, with various down-stream effects, following brain ischemia. Methods: A permanent middle cerebral artery occlusion (PMCAo) model was used in PAR1 KO and WT C57BL/6J male mice. Mice were evaluated for neurological deficits (neurological severity score, NSS), infarct volume (Tetrazolium Chloride, TTC), and for plasmin and thrombin activity in brain slices. Results: Significantly low levels of plasmin and thrombin activities were found in PAR1 KO compared to WT (1.6±0.4 vs. 3.2±0.6 ng/μl, p

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0248431

DOI: 10.1371/journal.pone.0248431

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