Effect of acute alcohol intoxication on mortality, coagulation, and fibrinolysis in trauma patients

Il-Jae Wang, Byung-Kwan Bae, Young Mo Cho, Suck Ju Cho, Seok-Ran Yeom, Sang-Bong Lee, Mose Chun, Hyerim Kim, Hyung-Hoi Kim, Sun Min Lee, Up Huh and Soo Young Moon

PLOS ONE, 2021, vol. 16, issue 3, 1-11

Abstract: Background: The effect of alcohol on the outcome and fibrinolysis phenotype in trauma patients remains unclear. Hence, we performed this study to determine whether alcohol is a risk factor for mortality and fibrinolysis shutdown in trauma patients. Materials and methods: A total of 686 patients who presented to our trauma center and underwent rotational thromboelastometry were included in the study. The primary outcome was in-hospital mortality. Logistic regression analysis was performed to determine whether alcohol was an independent risk factor for in-hospital mortality and fibrinolysis shutdown. Results: The rate of in-hospital mortality was 13.8% and blood alcohol was detected in 27.7% of the patients among our study population. The patients in the alcohol-positive group had higher mortality rate, higher clotting time, and lower maximum lysis, more fibrinolysis shutdown, and hyperfibrinolysis than those in the alcohol-negative group. In logistic regression analysis, blood alcohol was independently associated with in-hospital mortality (odds ratio [OR] 2.578; 95% confidence interval [CI], 1.550–4.288) and fibrinolysis shutdown (OR 1.883 [95% CI, 1.286–2.758]). Within the fibrinolysis shutdown group, blood alcohol was an independent predictor of mortality (OR 2.168 [95% CI, 1.030–4.562]). Conclusions: Alcohol is an independent risk factor for mortality and fibrinolysis shutdown in trauma patients. Further, alcohol is an independent risk factor for mortality among patients who experienced fibrinolysis shutdown.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0248810

DOI: 10.1371/journal.pone.0248810

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