Prognostic and clinicopathological significance of GPRC5A in various cancers: A systematic review and meta-analysis

Lu Dai, Xiao Jin and Zheng Liu

PLOS ONE, 2021, vol. 16, issue 3, 1-18

Abstract: Background: GPRC5A is associated with various cancer initiation and progression. Controversial findings have been reported about GPRC5A prognostic characteristics, and no meta-analysis has been conducted to assess the relationship between GPRC5A and cancer prognosis. Therefore, the objective of this meta-analysis is to evaluate the overall prognostic effectiveness of GPRC5A. Methods: We first conducted a systematic search in the PubMed, Embase, Web of Science, CNKI, Cochrane, and WangFang databases. The hazard ratio (HR) and odds ratios (OR) with 95% CI were then pooled to assess the associations between GPRC5A expression and overall survival (OS), disease-free survival (DFS), event-free survival (EFS), and clinicopathological characteristics. Chi-squared test and I2 statistics were completed to evaluate the heterogeneity in our study. A random‐effects model was used when significant heterogeneity existed (I2>50% and p

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0249040

DOI: 10.1371/journal.pone.0249040

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