The effect of intraocular pressure elevation and related ocular biometry changes on corneal OCT speckle distribution in porcine eyes

Marcela Niemczyk, Monika E Danielewska, Malgorzata A Kostyszak, Daniel Lewandowski and D Robert Iskander

PLOS ONE, 2021, vol. 16, issue 3, 1-18

Abstract: The aim of this study was to evaluate the influence of increase in intraocular pressure (IOP) and cooccurring changes in ocular biometry parameters on the corneal optical coherence tomography (OCT) speckle distribution in ex-vivo experiments on porcine intact eyes. Twenty-three eyeballs were used in the inflation test where IOP in the anterior chamber was precisely set from 10 mmHg to 40 mmHg in steps of 5 mmHg and where eye biometry was utilized (IOL Master 700). To assess the influence of the duration of the experiment on the OCT speckle statistics, the second experiment was performed with 10 eyeballs at the constant IOP of 15 mmHg. Based on the OCT scans of central cornea (Copernicus REVO), spatial maps of the scale parameter (a) and the shape parameter (v) of the gamma distribution speckle model were estimated. The means of both parameters for each spatial map were computed within the 2 mm of the central stroma. Both distributional parameters statistically significantly varied with IOP and time (one way repeated measures ANOVA, all p-values

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0249213

DOI: 10.1371/journal.pone.0249213

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