Food insecurity, drug resistance and non-disclosure are associated with virologic non-suppression among HIV pregnant women on antiretroviral treatment

Bhavna H Chohan, Keshet Ronen, Brian Khasimwa, Daniel Matemo, Lusi Osborn, Jennifer A Unger, Alison L Drake, Ingrid A Beck, Lisa M Frenkel, John Kinuthia and Grace John-Stewart

PLOS ONE, 2021, vol. 16, issue 8, 1-10

Abstract: We determined social and behavioral factors associated with virologic non-suppression among pregnant women receiving Option B+ antiretroviral treatment (ART). Baseline data was used from women in Mobile WAChX trial from 6 public maternal child health (MCH) clinics in Kenya. Virologic non-suppression was defined as HIV viral load (VL) ≥1000 copies/ml. Antiretroviral resistance testing was performed using oligonucleotide ligation (OLA) assay. ART adherence information, motivation and behavioral skills were assessed using Lifewindows IMB tool, depression using PHQ-9, and food insecurity with the Household Food Insecurity Access Scale. Correlates of virologic non-suppression were assessed using Poisson regression. Among 470 pregnant women on ART ≥4 months, 57 (12.1%) had virologic non-suppression, of whom 65% had HIV drug resistance mutations. In univariate analyses, risk of virologic non-suppression was associated with moderate-to-severe food insecurity (RR 1.80 [95% CI 1.06–3.05]), and varied significantly by clinic site (range 2%-22%, p

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0256249

DOI: 10.1371/journal.pone.0256249

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