Effect of TSH stimulation protocols on adequacy of low-iodine diet for radioiodine administration

Hwanhee Lee, Jin Chul Paeng, Hongyoon Choi, Sun Wook Cho, Young Joo Park, Do Joon Park, Young Ah Lee, June-Key Chung, Keon Wook Kang and Gi Jeong Cheon

PLOS ONE, 2021, vol. 16, issue 9, 1-11

Abstract: Low-iodine diet (LID) is a crucial preparation for radioactive iodine (RAI) treatment or scan in thyroid cancer. The aim of this study is to analyze the influence of thyroid stimulating hormone (TSH) stimulation protocols and other clinical factors on LID adequacy. Thyroid cancer patients who underwent LID for RAI scan or treatment were retrospectively analyzed. Patients were guided to have LID for 2 weeks before RAI administration and urine iodine/creatinine ratio (UICR, μg/g Cr) was measured. TSH stimulation was conducted using either thyroid hormone withdrawal (THW) or recombinant human TSH (rhTSH) injection. Adequacy of LID was classified by UICR as ‘excellent ( 250)’. A total of 1715 UICR measurements from 1054 patients were analyzed. UICR was significantly higher in case of rhTSH use than THW (72.4 ± 48.1 vs. 29.9 ± 45.8 μg/g Cr, P

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0256727

DOI: 10.1371/journal.pone.0256727

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