Prognostic value of postoperative decrease in serum albumin on surgically resected early-stage non-small cell lung carcinoma: A multicenter retrospective study

Fumihiko Kinoshita, Tetsuzo Tagawa, Takanori Yamashita, Tomoyoshi Takenaka, Taichi Matsubara, Gouji Toyokawa, Kazuki Takada, Taro Oba, Atsushi Osoegawa, Koji Yamazaki, Mitsuhiro Takenoyama, Mototsugu Shimokawa, Naoki Nakashima and Masaki Mori

PLOS ONE, 2021, vol. 16, issue 9, 1-14

Abstract: Background: Preoperative nutritional status is an important host-related prognostic factor for non-small cell lung carcinoma (NSCLC); however, the significance of postoperative changes in nutritional status remains unclear. This study aimed to elucidate the significance of postoperative decreases in serum albumin (ΔAlb) on the outcomes of early-stage NSCLC. Methods: We analyzed 443 training cohort (TC) and 642 validation cohort (VC) patients with pStage IA NSCLC who underwent surgery and did not recur within 1 year. We measured preoperative serum albumin levels (preAlb) and postoperative levels 1 year after surgery (postAlb), and calculated ΔAlb as (preAlb − postAlb)/preAlb × 100%. A cutoff value of 11% for ΔAlb was defined on the basis of the receiver operating characteristic curve for the TC. Results: Patients were divided into ΔAlb-Decreased and ΔAlb-Stable groups, including 100 (22.6%) and 343 (77.4%) in the TC, and 58 (9.0%) and 584 (90.1%) in the VC. ΔAlb-Decreased was associated with male sex (p = 0.0490), smoking (p = 0.0156), and non-adenocarcinoma (p

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0256894

DOI: 10.1371/journal.pone.0256894

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