Potential biomarkers of major depression diagnosis and chronicity

Ana Cecília de Menezes Galvão, Raíssa Nobrega Almeida, Geovan Menezes de Sousa Júnior, Mário André Leocadio-Miguel, Fernanda Palhano-Fontes, Dráulio Barros de Araujo, Bruno Lobão-Soares, João Paulo Maia- de-Oliveira, Emerson Arcoverde Nunes, Jaime Eduardo Cecilio Hallak, Jerome Sarris and Nicole Leite Galvão-Coelho

PLOS ONE, 2021, vol. 16, issue 9, 1-17

Abstract: Background: Molecular biomarkers are promising tools to be routinely used in clinical psychiatry. Among psychiatric diseases, major depression disorder (MDD) has gotten attention due to its growing prevalence and morbidity. Methods: We tested some peripheral molecular parameters such as serum mature Brain-Derived Neurotrophic Factor (mBDNF), plasma C-Reactive Protein (CRP), serum cortisol (SC), and the salivary Cortisol Awakening Response (CAR), as well as the Pittsburgh sleep quality inventory (PSQI), as part of a multibiomarker panel for potential use in MDD diagnosis and evaluation of disease’s chronicity using regression models, and ROC curve. Results: For diagnosis model, two groups were analyzed: patients in the first episode of major depression (MD: n = 30) and a healthy control (CG: n = 32). None of those diagnosis models tested had greater power than Hamilton Depression Rating Scale-6. For MDD chronicity, a group of patients with treatment-resistant major depression (TRD: n = 28) was tested across the MD group. The best chronicity model (p

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0257251

DOI: 10.1371/journal.pone.0257251

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