Sex-based differences in the manifestations and complications of sickle cell disease: Report from the Sickle Cell Disease Implementation Consortium

Rita V Masese, Dominique Bulgin, Mitchell R Knisely, Liliana Preiss, Eleanor Stevenson, Jane S Hankins, Marsha J Treadwell, Allison A King, Victor R Gordeuk, Julie Kanter, Robert Gibson, Jeffrey A Glassberg, Paula Tanabe, Nirmish Shah and on behalf of the Sickle Cell Disease Implementation Consortium

PLOS ONE, 2021, vol. 16, issue 10, 1-16

Abstract: Introduction: Sex-based clinical outcome differences in sickle cell disease (SCD) remain largely unknown despite evidence that female sex is associated with an increased lifespan. To better characterize sex-based differences in SCD, we assessed pain, treatment characteristics, laboratory measures and complications among males and females currently enrolled in the Sickle Cell Disease Implementation Consortium (SCDIC) registry. Methods: The SCDIC consists of eight comprehensive SCD centers and one data coordinating center that received funding from the National Heart Lung and Blood Institute to improve outcomes for individuals with SCD. Eligibility criteria included: 15 to 45 years of age and a confirmed diagnosis of SCD. Self-report surveys were completed and data were also abstracted from the participants’ medical records. Results: A total of 2,124 participants were included (mean age: 27.8 years; 56% female). The majority had hemoglobin SS SCD genotype. Females had worse reports of pain severity (mean (SD) T-score 51.6 (9.6) vs 49.3 (10), p

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0258638

DOI: 10.1371/journal.pone.0258638

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