PET metabolic tumor volume as a new prognostic factor in childhood rhabdomyosarcoma

Helio Fayolle, Nina Jehanno, Valerie Lauwers-Cances, Marie-Pierre Castex, Daniel Orbach, Thomas Mognetti, Corradini Nadège, Pierre Payoux and Anne Hitzel

PLOS ONE, 2022, vol. 17, issue 1, 1-17

Abstract: Purpose: Childhood RMS is a rare malignant disease in which evaluation of tumour spread at diagnosis is essential for therapeutic management. F-18 FDG-PET imaging is currently used for initial RMS disease staging. Materials and methods: This multicentre retrospective study in six French university hospitals was designed to analyse the prognostic accuracy of MTV at diagnosis for patients with RMS between 1 January 2007 and 31 October 2017, for overall (OS) and progression-free survival (PFS). MTV was defined as the sum of the primitive tumour and the largest metastasis, where relevant, with a 40% threshold of the primary tumour SUVmax. Additional aims were to define the prognostic value of SUVmax, SUVpeak, and bone lysis at diagnosis. Results: Participants were 101 patients with a median age of 7.4 years (IQR [4.0-12.5], 62 boys), with localized disease (35 cases), regional nodal spread (43 cases), or distant metastases (23). 44 patients had alveolar subtypes. In a univariate analysis, a MTV greater than 200 cm3 was associated with OS (HR = 3.47 [1.79;6.74], p

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0261565

DOI: 10.1371/journal.pone.0261565

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