Efficacy and safety of Yunkang oral liquid combined with conventional therapy for threatened miscarriage of first-trimester pregnancy a protocol for systematic review and meta-analysis

Peng Sun, Liping Tang, Dongmei Yan, Bin Li, Lingxia Xu and Fei Wang

PLOS ONE, 2022, vol. 17, issue 2, 1-9

Abstract: Introduction: Threatened miscarriages is a common complication of first-trimester pregnancy. Due to the beneficial effects, there are increasing clinical studies on Yunkang oral liquid(YKOL). However, the efficacy and safety of YKOL are still unknown. The aim of this systematic review was to assess the efficacy and safety of YKOL in the treatment of threatened miscarriage during the first-trimester pregnancy (TMFP). Methods: This protocol will be prepared according to the preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) statement. The systematic review will include all randomized controlled trials (RCTs) studies published until April 2021. Electronic sources including CNKI, WF, VIP, CBM, MEDLINE(PubMed), Embase, Cochrane Library, and Web of Science will be searched for potentially eligible studies. The international clinical trial registration platform and the Chinese clinical trial registration platform of controlled trials will be searched from their inception until April 1st, 2021. According to the inclusion and exclusion criteria, screening literature, extraction data will be conducted by two researchers independently. Statistical analysis will use RevMan 5.3.5 software. The strength of evidence from the studies will be evaluated with the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) methods. Results: This study will provide evidence for YKOL combined with conventional therapy for TMFP. Conclusion: The efficacy and safety of YKOL combined with conventional therapy for TMFP will be assessed. Systematic review registration: INPLASY202140105 (https://www.doi.org/10.37766/inplasy2021.4.0105).

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0263581

DOI: 10.1371/journal.pone.0263581

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