The minipig intraoral dental implant model: A systematic review and meta-analysis

Marta Liliana Musskopf, Amanda Finger Stadler, Ulf ME Wikesjö and Cristiano Susin

PLOS ONE, 2022, vol. 17, issue 2, 1-17

Abstract: Objectives: The objective of this report was to provide a review of the minipig intraoral dental implant model including a meta-analysis to estimate osseointegration and crestal bone remodeling. Methods: A systematic review including PubMed and EMBASE databases through June 2021 was conducted. Two independent examiners screened titles/abstracts and selected full-text articles. Studies evaluating titanium dental implant osseointegration in native alveolar bone were included. A quality assessment of reporting was performed. Random-effects meta-analyses and meta-regressions were produced for bone-implant contact (BIC), first BIC, and crestal bone level. Results: 125 out of 249 full-text articles were reviewed, 55 original studies were included. Quality of reporting was generally low, omissions included animal characteristics, examiner masking/calibration, and sample size calculation. The typical minipig model protocol included surgical extraction of the mandibular premolars and first molar, 12±4 wks post-extraction healing, placement of three narrow regular length dental implants per jaw quadrant, submerged implant healing and 8 wks of osseointegration. Approximately 90% of studies reported undecalcified incandescent light microscopy histometrics. Overall, mean BIC was 59.88% (95%CI: 57.43–62.33). BIC increased significantly over time (p 90%, p

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0264475

DOI: 10.1371/journal.pone.0264475

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