Genetic and chemical markers for authentication of three Artemisia species: A. capillaris, A. gmelinii, and A. fukudo

Yun Sun Lee, Sunmin Woo, Jin-Kyung Kim, Jee Young Park, Nur Kholilatul Izzah, Hyun-Seung Park, Jung Hwa Kang, Taek Joo Lee, Sang Hyun Sung, Kyo Bin Kang and Tae-Jin Yang

PLOS ONE, 2022, vol. 17, issue 3, 1-15

Abstract: The genus Artemisia is an important source of medicines in both traditional and modern pharmaceutics, particularly in East Asia. Despite the great benefits of herbal medicine, quality assessment methods for these medicinal herbs are lacking. The young leaves from Artemisia species are generally used, and most of the species have similar morphology, which often leads to adulteration and misuse. This study assembled five complete chloroplast genomes of three Artemisia species, two accessions of A. gmelinii and A. capillaris, and one A. fukudo. Through comparative analysis, we revealed genomic variations and phylogenetic relationships between these species and developed seven InDel-based barcode markers which discriminated the tested species from each other. Additionally, we analyzed specialized metabolites from the species using LC-MS and suggested chemical markers for the identification and authentication of these herbs. We expect that this integrated and complementary authentication method would aid in reducing the misuse of Artemisia species.

Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0264576

DOI: 10.1371/journal.pone.0264576

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